The play is 49ers/Bills Over 43. This game will be high-scoring and even though the weather is cold, there will be points scored on both sides.
You just don't hold a Mike Martz offense down for the whole game and the Bills gave up 31 points to the lowly Chiefs last week, and scored 54 themselves.
Wind is the biggest factor in affecting passing games of teams and the wind won't be a huge factor tonight. Bank on a few turnovers today which will help field position for both teams.